POSITIVE END-EXPIRATORY PRESSURE SETTING IN COVID-19-RELATED ACUTE RESPIRATORY DISTRESS SYNDROME: COMPARISON BETWEEN ELECTRICAL IMPEDANCE TOMOGRAPHY, PEEP/FIO2 TABLES, AND TRANSPULMONARY PRESSURE

Positive End-Expiratory Pressure Setting in COVID-19-Related Acute Respiratory Distress Syndrome: Comparison Between Electrical Impedance Tomography, PEEP/FiO2 Tables, and Transpulmonary Pressure

Introduction: The best way to titrate the positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate.Electrical Lunchbox impedance tomography (EIT) is a non-invasive technique that could guide PEEP setting based on an optimized ventilation homogeneity.Methods: For this study, we

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Segregating domain-general from emotional context-specific inhibitory control systems - ventral striatum and orbitofrontal cortex serve as emotion-cognition integration hubs

Inhibitory control hierarchically regulates cognitive and emotional systems in the service of adaptive goal-directed behavior across changing task demands and environments.While previous studies convergently determined the contribution of prefrontal-striatal systems to general inhibitory control, findings on the specific circuits that mediate emoti

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Trans fatty acids (tFA): sources and intake levels, biological effects and content in commercial Spanish food Ácidos grasos trans (AGt): fuentes y niveles de ingesta, efectos biológicos y contenido en los alimentos comerciales españoles

Recent studies of dietary habits in children and adolescents performed in Spain show that a high percentage of the daily energy intake corresponds to fat (42.0-43.0%).These findings show an excessive contribution of saturated fatty acids and also a considerable supply of trans fatty acids.These compounds are formed generally during partial Mountain

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Bright future or blind alley? CAR-T cell therapy for solid tumors

Chimeric antigen receptor (CAR) T cells therapy has emerged as a significant breakthrough in adoptive immunotherapy for hematological malignancies with FDA approval.However, the application of CAR-T cell therapy in solid tumors remains challenging, mostly due to lack of suitable CAR-T target antigens, insufficient trafficking and extravasation to t

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